Prof Peng Liu

Prof Peng Liu

Professor

Affiliation: Tsinghua University, Beijing, China

Research Focus: Microfluidics, DNA sequencing, Lab automation, Point-of-care diagnostics

Biography

Prof Peng Liu is a Professor at Tsinghua University School of Medicine, specializing in microfluidics technology and its applications in biomedical analysis. Since the inception of microfluidic technology in the 1990s, various miniaturized and integrated microsystems have been developed and are poised to advance analytical tools in scientific study, and even to change our daily lives.

Aiming to bring microfluidics from laboratories to practical applications, Prof Liu's research focuses on the development of integrated and miniaturized microfluidic systems for high-performance genetic analysis, cell analysis, and laboratory automation. His work bridges the gap between fundamental microfluidic research and real-world clinical and forensic applications.

Prof Liu has made significant contributions to the development of portable and automated microsystems for DNA analysis, including groundbreaking work in forensic short tandem repeat (STR) analysis, clinical targeted DNA sequencing, and circulating tumor cell detection. His research has been published in top-tier journals including Lab on a Chip, Analytical Chemistry, and Trends in Biotechnology.

Research Areas

  • Microfluidics technology and miniaturized analytical systems
  • Fully integrated microsystems for targeted DNA sequencing for clinical diagnosis
  • Automated and portable microsystems for on-site forensic short tandem repeat (STR) analysis
  • Microfluidic tools for separation and analysis of specific cells, such as circulating tumor cells
  • Miniaturized and integrated cell screening platforms for targeted gene editing
  • Lab-on-a-chip systems for point-of-care diagnostics
  • Capillary electrophoresis microchips for genetic analysis

Selected Publications

  • Liu, P., Meagher, R.J., Light, Y.K., et al. Microfluidic fluorescence in situ hybridization and flow cytometry (µFlowFISH) for environmental bacterial detection. Lab on a Chip 11, 2673-2679 (2011).
  • Liu, P., Scherer, J.R., Greenspoon, S.A., et al. Integrated sample cleanup and capillary array electrophoresis microchip for forensic short tandem repeat analysis. Forensic Science International: Genetics 5, 484-492 (2011).
  • Liu, P., Li, X., Greenspoon, S.A. and Mathies, R.A. Integrated DNA purification, PCR, sample cleanup, and capillary electrophoresis microchip for forensic human identification. Lab on a Chip 11, 1041-1048 (2011).
  • Liu, P. and Mathies, R.A. Integrated microfluidic systems for high-performance genetic analysis. Trends in Biotechnology 27, 572-581 (2009).
  • Liu, P., Yeung, S.H.I., Crenshaw, K.A., et al. Real-time forensic DNA analysis at a crime scene using a portable microchip analyzer. Forensic Science International: Genetics 2, 301-309 (2008).
  • Liu, P., Seo, T.S., Beyor, N., et al. Integrated portable PCR-Capillary electrophoresis microsystem for rapid forensic short tandem repeat typing. Analytical Chemistry 79, 1881-1889 (2007).